Abstract Background Overcoming the notorious apoptotic resistance of melanoma cells remains a therapeutic challenge given dismal survival of patients with metastatic melanoma.However, recent clinical trials using a BRAF inhibitor revealed encouraging results for patients with advanced BRAF mutant bearing melanoma, but drug resistance accompanied by
A well-known issue for social media sites consists of the hazy boundaries between malicious false news and protected speech satire.In addition to the protective measures that lessen the exposure of false material on social media, providers of fake news have started to pose as satire sites in order to escape being delisted.Potentially, this may caus
The study is focused on the mineralogy of rare-element rich tourmaline-bearing miarolitic pegmatities of the Shakhdarinskaya vein (SW Pamirs, Tajikistan).The results of the study are crucially important for understanding the regularities of distribution and behavior of Li, Rb and Cs in the course of crystallization of the most low-temperature pegma
An engineering design procedure for calculating bending with Pucks torsion in corrugated beams, including finding the critical load of general stability, implemented in the commonly used MS Excel spreadsheet and verified in the LIRA-SAPR software package, has been proposed.The method makes it possible to take into account the beams section variabil